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Enzymes are large molecules that accelerate chemical reactions. By accelerating reactions they ensure that a particular substrate is converted to a product. The human body uses enzymes to safely speed up many biochemical processes. One example is proteases in the stomach that assist in digesting food. One benefit of using enzymes over small molecules is that enzymes are highly specific for their particular substrate; thus, only that specific reaction will be allowed to ensue.

 How Does It Work

Captozyme's enzyme therapeutic contain oxalate-degrading enzymes that remove non-nutrient oxalate from the diet and body of patients in need. Recurrent stone formers can benefit from reducing systemic oxalate levels. Captozyme's enzyme therapeutics are able to actively degrade oxalate throughout the intestinal tract and thus use the complete extent of this vast organ for oxalate removal.

 Pre-Clinical Results

Captozyme’s proprietary oxalate-degrading enzymes have been evaluated in hyperoxaluric male beagle dogs and preliminary data demonstrate a urinary reduction up to 40-50%. Six male beagle dogs were made hyperoxaluric through dietary oxalate. Unformulated enzymes were administrated by oral gavage following a meal. Oxalate reduction was monitored by urinary oxalate determination using standard procedures.


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